Patent Claim: Nicotine Alternative Cytisine in Future E-liquid?

The subject of the invention is a e-liquid with an addition of organic chemical compound with formula Cj 1H14 2O named popularly Cytisine to be used in electronic cigarettes and related tobacco industry products for the purposes of substitution therapy in treatment of the nicotine addiction syndrome.

In the current state of the art, the tobacco industry manufactures many types of liquids to be used to refill electronic cigarettes for the purpose of inhaling vapours containing nicotine. The cigarettes, called also e-cigarettes, are usually made of plastics and house cartridges with a dose of nicotine released by a mechanism mounted inside a device imitating functional features of traditional cigarettes. E-cigarettes neither contain any combustible plant material nor generate any cigarette smoke; however, they contain nicotine as well as aromatic substances and produce nicotine-containing vapours.

It is desirable to develop effective products that could be used as a measure for the purpose of the nicotine substitution therapy. Cytisine demonstrates effects similar to those produced by nicotine, has a stimulating effect on autonomic nervous system, mainly the respiratory centre. It stimulates also the vasomotor centre, increases secretion of adrenaline and results in an increase of blood pressure.

Currently, cytisine is administered in small doses in the form of tablets, as a substitute for nicotine in mitigation of nicotine cravings in the course of therapies aimed at reduction of negative effects of nicotinism. It has been proven that cytisine shows less addictive properties than nicotine and is useful in mitigation of nicotine craving symptoms.

At present, any solutions consisting in enriching liquids for electronic cigarettes with cytisine according to the method characteristic to “a liquid with cytisine for electronic cigarettes” are not know.

The objective of the invention entitled “A liquid with cytisine for electronic cigarettes” is to provide a liquid for e-cigarettes containing an addition of extracted or synthetically obtained cytisine in a dose ranging from 0.000000001% to 99.999999999% of given liquid volume.

This problem has been solved by combining a liquid, solution, and/or emulsion or a mixture thereof in the amount of from 0.000000001% to 99.999999999% of given quantity of the liquefied mass with a dose of cytisine ranging from 0.000000001%) to 99.999999999% in such a way that the added cytisine increases the mass of said liquid and changes its properties, as a result of which a liquid is obtained characterised in that it contains substances other than nicotine in the amount from 0.000000001% to 99.999999999% of the liquid volume and a dose of cytisine in the amount from 0.000000001% to 99.999999999%.

In the technological process of manufacturing the liquid according to the invention, cytisine is placed in the volume of the liquid.

A distinctive feature of the solution with respect to known solutions of the so-called e-liquids consists in combination of a given dose of cytisine and a liquid into a single product with properties of a liquid is such a way that, contrary to traditional liquids, it contains a measured dose of cytisine. Intermediate products in the manufacturing process are: a liquid material prepared according to any formula applied by tobacco industry manufacturers and cytisine of natural origin and/or obtained synthetically, as a result of genetic modification, or a combination of these processes.

An embodiment of the solution according to the invention is described in the following as an example process of producing a unit volume of liquid with cytisine:

Cytisine is placed in glycol solution in the proportion of 90% glycol and 10% cytisine by weight as granulate, powder, emulsion, suspension, solution, deposit, material, conglomerate and/or a mixture with arbitrary proportions of these intermediate products obtained by means of chemical reactions, physical processes, genetic modifications or any combination thereof, and then subject to further processing.

The liquids manufactured according to the invented method, when applied in vapour generators known commonly as electronic cigarettes and inhaled the form of vapours, allow to release cytisine of organic origin or obtained synthetically. Cytisine contained in the smoke of such cigarette in doses according to the invention and released from electronic cigarette gets inside, through lungs of the electronic cigarette user, to blood and produces its effect on organism of the smoking person.


source: Sumobrain

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